PBAT sequencing of primary first trimester cytotrophoblast and mural trophectoderm.

sequencing
Abstract
To assess whether the DNA methylation landscape of human trophoblast stem cells resembles an in vivo cell type, we used post-bisulfite adaptor-tag sequencing to measure genome-wide DNA methylation of preimplantation human trophectoderm and sorted first trimester cytotrophoblast.

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Papers

Ectopic expression of DNMT3L in human trophoblast stem cells restores features of the placental methylome
DOI:10.1016/j.stem.2024.12.007