ISS (in situ sequencing) Patcher
Abstract
iss_patcher is a simple package for approximating features not experimentally captured in low-dimensional data based on related, high-dimensional data. The shared feature space between the two objects is identified, and log-normalised and z-scored on a per-object basis. The nearest neighbours of the low-dimensional observations in the high-dimensional space are identified, and the counts of the absent features are approximated as the mean of the high-dimensional neighbours. While the function was initially written for processing ISS and GEX data, it can in principle be used for any sort of low-dimensional data featuring a subset of features from high-dimensional data.
Files
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