{"id":["DOI:10.1016/j.cell.2023.11.013"],"title":["A tridimensional atlas of the developing human head"],"publication_date":["2023-12-21"],"authors":{"ORCID:0000-0002-8552-0229":{"id":["ORCID:0000-0002-8552-0229"],"family_name":["Blain"],"personal_name":["Raphael"],"affiliations":{"ROR:000zhpw23":{"organization_name":["Institut de la Vision"]}}},"AUTHTEMP:0007":{"id":["AUTHTEMP:0007"],"family_name":["Couly"],"personal_name":["Gérard"],"affiliations":{"ROR:000zhpw23":{"organization_name":["Institut de la Vision"]}}},"ORCID:0000-0002-8712-8431":{"id":["ORCID:0000-0002-8712-8431"],"family_name":["Shotar"],"personal_name":["Eimad"],"affiliations":{"ROR:000zhpw23":{"organization_name":["Institut de la Vision"]},"ROR:02en5vm52":{"organization_name":["Sorbonne Université"]}}},"ORCID:0009-0005-5800-3102":{"id":["ORCID:0009-0005-5800-3102"],"family_name":["Blévinal"],"personal_name":["Joséphine"],"affiliations":{"ROR:000zhpw23":{"organization_name":["Institut de la Vision"]}}},"ORCID:0009-0007-3508-4274":{"id":["ORCID:0009-0007-3508-4274"],"family_name":["Toupin"],"personal_name":["Maryne"],"affiliations":{"ROR:01p178v10":{"organization_name":["Institut de Recherche en Santé, Environnement et Travail"]}}},"ORCID:0009-0007-8825-2294":{"id":["ORCID:0009-0007-8825-2294"],"family_name":["Favre"],"personal_name":["Anais"],"affiliations":{"ROR:000zhpw23":{"organization_name":["Institut de la Vision"]}}},"AUTHTEMP:0008":{"id":["AUTHTEMP:0008"],"family_name":["Abjaghou"],"personal_name":["Ali"],"affiliations":{"ROR:000zhpw23":{"organization_name":["Institut de la Vision"]}}},"ORCID:0000-0002-4201-9215":{"id":["ORCID:0000-0002-4201-9215"],"family_name":["Inoue"],"personal_name":["Megumi"],"affiliations":{"ROR:000zhpw23":{"organization_name":["Institut de la Vision"]}},"HDBItheme":["BloodAndImmune"]},"ORCID:0000-0001-5677-9613":{"id":["ORCID:0000-0001-5677-9613"],"family_name":["Hernández-Garzón"],"personal_name":["Edwin"],"affiliations":{"ROR:000zhpw23":{"organization_name":["Institut de la Vision"]}}},"ORCID:0000-0002-6442-8239":{"id":["ORCID:0000-0002-6442-8239"],"family_name":["Clarençon"],"personal_name":["Frédéric"],"affiliations":{"ROR:02mh9a093":{"organization_name":["Pitié-Salpêtrière Hospital"]}}},"ORCID:0000-0002-0535-3628":{"id":["ORCID:0000-0002-0535-3628"],"family_name":["Chalmel"],"personal_name":["Frédéric"],"affiliations":{"ROR:01p178v10":{"organization_name":["Institut de Recherche en Santé, Environnement et Travail"]}}},"ORCID:0000-0003-0566-4124":{"id":["ORCID:0000-0003-0566-4124"],"family_name":["Mazaud-Guittot"],"personal_name":["Séverine"],"affiliations":{"ROR:01p178v10":{"organization_name":["Institut de Recherche en Santé, Environnement et Travail"]}}},"ORCID:0000-0002-3075-1441":{"id":["ORCID:0000-0002-3075-1441"],"family_name":["Giacobini"],"personal_name":["Paolo"],"affiliations":{"ROR:04p94ax69":{"organization_name":["Lille Neurosciences & Cognition"]}}},"ORCID:0000-0002-6808-6010":{"id":["ORCID:0000-0002-6808-6010"],"family_name":["Gitton"],"personal_name":["Yorick"],"affiliations":{"ROR:000zhpw23":{"organization_name":["Institut de la Vision"]}}},"ORCID:0000-0001-7577-3794":{"id":["ORCID:0000-0001-7577-3794"],"family_name":["Chédotal"],"personal_name":["Alain"],"affiliations":{"ROR:000zhpw23":{"organization_name":["Institut de la Vision"]},"ROR:029brtt94":{"organization_name":["Université Claude Bernard Lyon 1"]},"ROR:01502ca60":{"organization_name":["Hospices Civils de Lyon"]}},"HDBItheme":["BloodAndImmune"]}},"abstract":["The evolution and development of the head have long captivated researchers due to the crucial role of the head as the gateway for sensory stimuli and the intricate structural complexity of the head. Although significant progress has been made in understanding head development in various vertebrate species, our knowledge of early human head ontogeny remains limited. Here, we used advanced whole-mount immunostaining and 3D imaging techniques to generate a comprehensive 3D cellular atlas of human head embryogenesis. We present detailed developmental series of diverse head tissues and cell types, including muscles, vasculature, cartilage, peripheral nerves, and exocrine glands. These datasets, accessible through a dedicated web interface, provide insights into human embryogenesis. We offer perspectives on the branching morphogenesis of human exocrine glands and unknown features of the development of neurovascular and skeletomuscular structures. These insights into human embryology have important implications for understanding craniofacial defects and neurological disorders and advancing diagnostic and therapeutic strategies."],"HDBItheme":["BloodAndImmune"],"datasets":{"URL:https://hudeca.com/3D-models/Inserm-foets-responsive.html":{"id":["URL:https://hudeca.com/3D-models/Inserm-foets-responsive.html"],"title":["Interactive 3D reconstruction of the head arteries"],"description":["Model 1: Interactive 3D reconstruction of the head arteries (SMA+) of a PCW7 human embryo generated with Verge3D."],"tags":["imaging"]},"URL:https://hudeca.com/3D-models/Inserm-foetus2/Inserm-foetus2-responsive.html":{"id":["URL:https://hudeca.com/3D-models/Inserm-foetus2/Inserm-foetus2-responsive.html"],"title":["Interactive 3D reconstruction of the skeleton"],"description":["Model 2: Interactive 3D reconstruction of the skeleton (Col2+) of a PCW7 human embryo generated with Verge3D."],"tags":["imaging"]}},"code":{"SWHID:swh:1:dir:8d5f1e4bc519343c4e60c08c9841ca3186991406":{"id":["SWHID:swh:1:dir:8d5f1e4bc519343c4e60c08c9841ca3186991406"],"title":["Python notebooks for A tridimensional atlas of the developing human head."],"description":["Python notebooks used in Blain et al., 2023, \"A tridimensional atlas of the developing human head.\" "]}}}